The 5-Second Trick For indazole structure
Substitution at R3 that has a halogen or alkoxy group (74f–74i) triggered a slight boost in cellular potency Together with the halide analogs (74g–h) exhibiting maximum the potency inside the group. More optimization led to the discovery of 74i–j, with 74k as the most Lively compound while in the series (pIC50 = six.77) with excellent LLE val